Key result
Among patients with type 2 diabetes, there was a poor and non-significant correlation between oxidative stress parameters and serum nitric oxide levels across all groups (p>0.05).
Why the study?
Chronic hyperglycemia and diabetes lead to impaired nitric oxide production and activity, prompting assessment of serum nitric oxide levels and their correlation with lipid profile and oxidative stress.
Cross-Sectional (n=99)
No
This study found no significant correlation between serum nitric oxide levels and oxidative stress parameters or lipid profiles in patients with type 2 diabetes mellitus.
Answers are grounded in this paper and cite their sources.
NO assessment in diabetes should not guide care yet; leaves open correlations with lipids and oxidative stress.
Background and Aim: Endothelial dysfunction appears to be a consistent finding in all diabetic patients. Indeed, there is a general agreement that chronic hyperglycemia and DM lead to impairment in nitric oxide (NO) production and activity. The present study was conducted to assess the serum levels of NitricOxide (NO) among diabetic patients and its correlation with lipid profile as well as oxidative stress.Material and Methods: The present study was conducted among 99 patients of diabetes of both genders. The patients were divided into three groups: Group I were type 2 diabetics with dyslipidemia and hyperuricaemia, group II was type 2 diabetics with dyslipidemia and normouricaemia and group III was type 2 diabetics with normolipidemic and normouricaemia. Lipid profile and nitric oxide were determined.Results: There was a non-significant difference in HbA1c, TC, TG, HDL and LDL among different differences (P> 0.05). There was poor correlation of antioxidants with NO levels (P> 0.05)Conclusion: There was a role of Nitric Oxide (NO) in the pathogenesis of type -2 diabetes mellitus with dyslipidemia and hyperuricaemia. The oxidative stress parameters had poor correlation with NO level in all the groups.
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Chudasama et al. (2021) conducted a cross-sectional in Type 2 diabetes mellitus (n=99). Dyslipidemia and hyperuricaemia vs. Normolipidemia and normouricaemia was evaluated on Correlation of antioxidants with NO levels (p=>0.05). Among patients with type 2 diabetes, there was a poor and non-significant correlation between oxidative stress parameters and serum nitric oxide levels across all groups (p>0.05).
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