Key result
Adolescent type 1 diabetics show lower FMD, NO, and ADMA and higher OxLDL vs healthy volunteers.
Why the study?
The relationship between asymmetric dimethyl L-arginine, nitric oxide, and cardiovascular disease in adolescent type 1 diabetics was evaluated to understand their role in cardiac and renal dysfunction.
Are levels of ADMA, NO, and OxLDL altered in adolescent type 1 diabetics compared to healthy volunteers, and do they correlate with cardiovascular and renal dysfunction?
Case-Control (n=92)
Are levels of ADMA, NO, and OxLDL altered in adolescent type 1 diabetics compared to healthy volunteers, and do they correlate with cardiovascular and renal dysfunction?
Adolescent type 1 diabetics exhibit early signs of endothelial and diastolic dysfunction, which correlate with reduced nitric oxide and ADMA levels and elevated OxLDL.
Lower NO/ADMA levels were associated with endothelial and diastolic dysfunction in adolescent T1D; hypothesis-generating, prospective studies needed before clinical adoption.
OBJECTIVE: To evaluate asymmetric dimethyl L-arginine (ADMA), nitric oxide (NO) and cardiovascular disease in adolescent type 1 diabetics. METHODS: The study included 62 type 1 diabetic patients and 30 healthy volunteers of the same age and sex. Blood samples were taken for assessment of ADMA, NO, oxidized low density lipoprotein (OxLDL), glycosylated hemoglobin, and lipid profile. Urine samples were taken for assessment of albumin/creatinine ratio. M mode echocardiography and flow mediated dilatation (FMD) via ultrasound were completed; t-test for independent variables, Pearson's correlation, and stepwise multiple regression analysis were used. RESULTS: The mean age of patients was 16.3±1.5 years and mean duration of diabetes was 9.4±2.9 years. Nitric oxide, ADMA and FMD were significantly lower, while OxLDL and the albumin/creatinine ratio were significantly higher in diabetics. Nitric oxide had a significant negative correlation with left ventricular end-diastolic dimension, left ventricular end-systolic dimension, posterior wall thickness, left ventricular mass, albumin/creatinine ratio, and OxLDL, as well as a positive correlation with ADMA. Albumin/creatinine ratio had a significant positive correlation with OxLDL and negative correlation with ADMA. Stepwise multiple regression analysis revealed that ADMA is the only parameter related to NO, however, albumin/creatinine ratio and OxLDL are related to ADMA. CONCLUSIONS: Type 1 diabetic patients had endothelial and diastolic dysfunction. The reduction in NO, ADMA, and elevation of OxLDL, and its relation to echocardiographic data and albumin/creatinine ratio, may reflect their role in cardiac and renal affection.
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Dayem et al. (2014) conducted a case-control in Type 1 diabetes (n=92). Type 1 diabetes vs. Healthy volunteers was evaluated on Nitric oxide, ADMA, FMD, OxLDL, and albumin/creatinine ratio. Adolescent type 1 diabetics had significantly lower nitric oxide, ADMA, and flow-mediated dilatation, and higher OxLDL and albumin/creatinine ratio compared to healthy volunteers.
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