Key result
Atorvastatin significantly attenuated myocardial inflammation, oxidative stress, and lipid abnormalities induced by PM2.5 exposure in a rat model of atherosclerosis.
Why the study?
Does atorvastatin reduce myocardial inflammation and atherosclerosis markers in rats exposed to PM2.5?
Does atorvastatin reduce myocardial inflammation and atherosclerosis markers in rats exposed to PM2.5?
p-value: p=<0.05
Atorvastatin attenuates myocardial inflammation and improves lipid and oxidative stress profiles in a rat model of PM2.5 exposure.
Hypothesis-generating for statin protection against PM2.5 cardiac effects; leaves open translation to human atherosclerosis prevention.
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Yao et al. (2017) studied Atherosclerosis (n=32). Atorvastatin vs. PM2.5 exposure without atorvastatin was evaluated on Myocardial inflammation and oxidative stress markers (p=<0.05). Atorvastatin significantly attenuated myocardial inflammation, oxidative stress, and lipid abnormalities induced by PM2.5 exposure in a rat model of atherosclerosis.
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