Key result
Apolipoprotein A-II, like apo A-I, reacts poorly with DMPC membranes containing ≥20 mol % free cholesterol, suggesting intrahepatically formed apo A-II HDL are likely cholesterol-rich.
Population
In vitro model using human plasma apolipoprotein A-II, its reduced and carboxymethylated monomer, and…
Design
Preclinical
Authors
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Should not yet inform clinical HDL assessment; hypothesis-generating for cholesterol-rich apo A-II particles in hepatic metabolism.
Apolipoprotein A-II requires membrane surface defects to form rHDL, which disappear at 20 mol % free cholesterol, suggesting intrahepatic apo A-II HDL are cholesterol-rich.
Bassett et al. (2012) studied this question. Apolipoprotein A-II vs. Apolipoprotein A-I was evaluated on Rate of rHDL formation. Apolipoprotein A-II, like apo A-I, reacts poorly with DMPC membranes containing ≥20 mol % free cholesterol, suggesting intrahepatically formed apo A-II HDL are likely cholesterol-rich.
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