Key result
Anti-idiotypic antibodies to anti-FMDV neutralizing monoclonal antibodies failed to react with cellular receptors for the virus but induced non-neutralizing anti-viral antibodies in mice.
Anti-idiotypic antibodies against FMDV neutralizing monoclonal antibodies can induce anti-viral antibodies in mice, suggesting potential as an alternative vaccine strategy despite not reacting with cellular receptors.
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Hypothesis-generating for anti-idiotypic FMDV vaccines in mice; leaves open translation to livestock or humans.
Baxt et al. (1989) studied Foot-and-mouth disease virus (FMDV). Anti-idiotypic antibodies against FMDV neutralizing monoclonal antibodies was evaluated on Cross-reactivity, binding to cells, and induction of anti-viral antibodies. Anti-idiotypic antibodies to anti-FMDV neutralizing monoclonal antibodies failed to react with cellular receptors for the virus but induced non-neutralizing anti-viral antibodies in mice.
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