Key result
Smooth muscle-specific knockout of NCX1 in mice reduced mean blood pressure by 6-10 mmHg compared to wild-type controls and attenuated myogenic tone and L-type Ca2+ channel currents.
Population
Mice with smooth muscle-specific knockout of Na+/Ca2+ exchanger type-1 (NCX1), wild-type controls, and…
Comparison
Smooth muscle-specific knockout of NCX1 and/or… vs Wild-type (WT) controls and NCX1(Fx/-) mice
Design
Preclinical
Authors
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NCX1 contributes to myogenic tone and BP in mice; leaves open whether selective inhibition offers a viable antihypertensive strategy in humans.
NCX1-mediated Ca2+ entry in smooth muscle contributes significantly to the maintenance of myogenic tone and blood pressure in mice.
Zhang et al. (2010) studied this question. Smooth muscle-specific knockout of Na+/Ca2+ exchanger type-1 (NCX1(SM-/-)) vs. Wild-type (WT) controls was evaluated on Mean blood pressure and myogenic tone. Smooth muscle-specific knockout of NCX1 in mice reduced mean blood pressure by 6-10 mmHg compared to wild-type controls and attenuated myogenic tone and L-type Ca2+ channel currents.
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