Key result
Superoxide dismutase (50.0 mg/kg) or catalase (1.0 mg/kg) demonstrated a preventive and protective effect against endotoxin-induced experimental disseminated intravascular coagulation in rats.
Why the study?
Does superoxide dismutase or catalase prevent endotoxin-induced disseminated intravascular coagulation in rats?
Does superoxide dismutase or catalase prevent endotoxin-induced disseminated intravascular coagulation in rats?
High doses of superoxide dismutase or catalase protect against endotoxin-induced disseminated intravascular coagulation in a rat model.
Authors
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No immediate clinical role in human DIC; leaves open translation of antioxidant effects from rat endotoxin models.
Yoshikawa et al. (1983) studied Endotoxin-induced experimental disseminated intravascular coagulation (DIC). Superoxide dismutase (SOD) and catalase was evaluated on Coagulation parameters including fibrinogen, fibrin degradation products, prothrombin time, partial thromboplastin time, platelet count, and renal glomeruli with fibrin thrombi. Superoxide dismutase (50.0 mg/kg) or catalase (1.0 mg/kg) demonstrated a preventive and protective effect against endotoxin-induced experimental disseminated intravascular coagulation in rats.
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