The hydroperoxide-induced net release of Ca2+ from rat liver mitochondria is stimulated by the Ca2+ uptake inhibitor ruthenium red. At moderate Ca2+ loads the release takes place with preservation of a high mitochondrial membrane potential. During and after Ca2+ release mitochondria remain intact. The hydroperoxide-induced release of Ca2+ might therefore be of physiological relevance.
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Baumhüter et al. (1982) studied this question.