Histopathologic Changes in the Nervous System in Cases of Peptic Ulcer

The relationship of the nervous system to peptic ulcer has been studied heretofore primarily with reference to the question of factors existing in the nervous system which play a specific role in production of the ulcer. The forceful reopening of the question of the neurogenic origin of peptic ulcer by the Balfour Lecture of Cushing,1as well as subsequent reports, such as those by Grant,2and Masten and Bunts,3makes it clear that lesions in certain areas of the central nervous system may be directly related to the production of ulcer by pathologic alteration of visceral centers and pathways. In the present inquiry it was soon learned that the nervous system may take part in the total clinical picture which constitutes the syndrome of peptic ulcer in other ways than that of causation. It seemed probable that the nervous system must also be looked on as the