Synthesis of Chiral Tetrahydroisoquinoline-Derived b-Amino Alcohols and Their Application to Asymmetric Reaction

Three chiral 1,2,3,4-tetrahydroisoquinoline-derived β-amino alcohols were synthesized by using the Ru-catalyzed asymmetric transfer hydrogenation of 6-methoxy-1-(2-methoxyphenyl)-3,4-dihydroisoquinoline as the key reaction. The ability of the synthesized β-amino alcohols as chiral ligands was evaluated in the addition of diethylzinc to benzaldehyde.