Abnormal conditions of congenital origin are a leading cause of death and disability in the United States. An estimated 500,000 fetal deaths and at least 62,000 deaths among the live-born are associated with birth defects each year. An estimated 15 million persons have one or more congenital defects which affect their daily lives. Birth defects constitute a leading cause of hospitalization of children.
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Virginia Apgar (1968) studied this question.
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