August 1, 1986European Heart Journal

Complementary role of thallium-201 scintigraphy to predischarge exercise electrocardiograph} for patients stratification after a first myocardial infarction

Q: What is the clinical evidence from this study?

Study design: Cohort. Population: first acute myocardial infarction (n=58). Intervention: Predischarge exercise test combined with thallium-201 myocardial scintigraphy vs. Exercise test alone. Primary outcome: Severe multivessel disease (MVD) on angiography at one month (p=<0.05).

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Key result

Predischarge exercise thallium-201 scintigraphy combined with exercise ECG significantly improved risk stratification for severe multivessel disease compared to exercise ECG alone (P<0.05).

Why the study?

Does a predischarge exercise test combined with thallium-201 myocardial scintigraphy improve the detection of severe multivessel disease in patients discharged after a first acute myocardial infarction?

Population

58 consecutive patients discharged after a first acute myocardial infarction

Comparison

Predischarge exercise test combined with… vs Predischarge exercise test alone

Design

Cohort

Follow-up

1 month

Authors

VLV. LEGRANDÉcole Nationale Supérieure de Chimie de Montpellier AAA. AlbertA. Alikhanyan National Laboratory PRP. RigoMasaryk University

Discussion

Member takes

Implication

May improve post-MI risk stratification for multivessel disease; hypothesis-generating and requires prospective validation.

Study Design

Type

Cohort (n=58)

Structured PICO

Population

58 consecutive patients discharged after a first acute myocardial infarction evaluated for severe multivessel disease.

Exposure

Predischarge exercise test combined with thallium-201 myocardial scintigraphy

Comparator

Predischarge exercise test alone

Outcome

Detection of severe multivessel disease (MVD) (>70% narrowing in vessels unrelated to infarction) on angiography at one monthsurrogate

Main Result

p-value: p=<0.05

Combining thallium-201 scintigraphy with predischarge exercise ECG improves risk stratification for multivessel disease in patients recovering from a first myocardial infarction compared to exercise testing alone.

Limitations

Exercise thallium scintigraphy at a submaximal level one or two weeks after infarction does not provide optimal information compared to studies performed at a later stage.
Exercise thallium scintigraphy at a submaximal level one or two weeks after infarction does not provide optimal information compared to studies performed at a later stage

Cite This Study

LEGRAND et al. (1986) conducted a cohort in first acute myocardial infarction (n=58). Predischarge exercise test combined with thallium-201 myocardial scintigraphy vs. Exercise test alone was evaluated on Severe multivessel disease (MVD) on angiography at one month (p=<0.05). Predischarge exercise thallium-201 scintigraphy combined with exercise ECG significantly improved risk stratification for severe multivessel disease compared to exercise ECG alone (P<0.05).

synapsesocial.com/papers/6a9ebdc4db61d4274d478c9d https://doi.org/10.1093/oxfordjournals.eurheartj.a062118

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Complementary role of thallium-201 scintigraphy to predischarge exercise electrocardiograph} for patients stratification after a first myocardial infarction

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

Complementary role of thallium-201 scintigraphy to predischarge exercise electrocardiograph} for patients stratification after a first myocardial infarction

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

Also Consider

Also Consider