February 17, 2004Stroke
Absence of Association Between Polymorphisms in the Hemostatic Factor Pathway Genes and Carotid Intimal Medial Thickness
Why the study?
Are polymorphisms in hemostatic factor pathway genes associated with increased carotid intimal medial thickness in adults?
Population
1,778 adults (867 men, 911 women) with a mean age of 57 years from the Framingham offspring cohort
Comparison
Presence of specific genetic polymorphisms in… vs Absence of these specific genetic polymorphisms
Design
Cross-sectional
Authors
Discussion
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Implication
Null findings for hemostatic polymorphisms and carotid IMT; leaves open effects on clinical events or other vascular phenotypes.
Structured PICO
Are polymorphisms in hemostatic factor pathway genes associated with increased carotid intimal medial thickness in adults?
P
Population
1,778 adults (867 men, 911 women) with a mean age of 57 years from the Framingham offspring cohort
I
Intervention
Presence of specific genetic polymorphisms in hemostatic factor pathways (factor V Leiden, factor VII Arg/Gln, fibrinogen HindIII beta-148, plasminogen activator inhibitor-1 4G/5G, and glycoprotein IIIa Pl(A2))
C
Comparator
Absence of these specific genetic polymorphisms (different genotypes)
O
Outcome
Mean internal (ICA) and common carotid artery (CCA) intimal medial thickness (IMT) measured by B-mode carotid ultrasonographysurrogate
Well-studied polymorphisms in hemostatic factor genes are not associated with subclinical atherosclerosis as measured by carotid IMT.
Cite This Study
Fox et al. (2004) studied this question.