Effect of Encapsulated Artemisia aucheri. L Magnetic Nanogel Extract on Shoulder Block in Rat

INTRODUCTION: Due to the severe pain generated after shoulder surgery, we aim to formulate and intravenously (IV) inject magnetic nanogel encapsulated Artemisia aucheri. L extract for inducing shoulder block in the rat. METHODS: Artemisia aucheri. L extract encapsulated magnetic nanoparticles (MNPs) was fabricated and tested in rat using paw withdrawal latencies (PWL) from thermal stimuli on the forepaw. The animals were divided into two groups; the untreated left forepaw (control group), and the test group with treated right forepaw. Sixteen (16) lab animals were used in this study, of which 3 in each of the two groups of the cumulative drug release experiments at 37°C and 43°C, and 5 in each of the two groups of PWL experiments. RESULTS: UV spectroscopy data shows that decreasing the pH of the fabricated nanocomposite has an influence on the extract release rate than increasing its temperature. CONCLUSIONS: The present study gave a proof of inducing a shoulder block in rat by IV injection administration of NIPAAM-MAA/Arthemisia aucheri. L extract complexes and magnet application to the shoulder. This will be a prospective formulation if a lower pH and temperature is considered for optimum release of this nanoanesthetics, thus, this can be translated into clinical practice for future applications.