Key result
A 77-year-old man with a large primary mediastinal well-differentiated liposarcoma underwent phrenic nerve-preserving marginal resection and remained asymptomatic at two years follow-up.
Case Report (n=1)
This case report demonstrates that marginal surgical resection of a massive primary mediastinal well-differentiated liposarcoma with preservation of phrenic nerves can yield favorable mid-term outcomes in patients with compromised respiratory function.
May support nerve-sparing resection in select mediastinal liposarcoma cases with respiratory compromise; leaves open validation in larger series.
Liposarcoma occurs very rarely in the mediastinum. Patients often remain asymptomatic until it grows large enough to cause direct invasion or compression of adjacent organs. We report a case of a 77-year-old male presented with dyspnea of exertion and was found to have a large mediastinal mass which was eventually diagnosed as primary mediastinal well-differentiated liposarcoma. The limited respiratory function at the initial presentation prompted phrenic nerve preserving incomplete resection rather than radical removal of the adjacent mediastinal structures. After surgical removal, the recurrence for well-differentiated mediastinal liposarcomas in the mediastinum is unknown; therefore, close follow-up is crucial.
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Fukuhara et al. (2014) conducted a case report in Primary mediastinal well-differentiated liposarcoma (n=1). Surgical resection (phrenic nerve preserving marginal resection) was evaluated on Patient outcome after surgery. A 77-year-old man with a large primary mediastinal well-differentiated liposarcoma underwent phrenic nerve-preserving marginal resection and remained asymptomatic at two years follow-up.
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