Population
Mice with bone fractures, including constitutive YAP/TAZ deletion models and adult onset-inducible knockout…
Comparison
Deletion of YAP and TAZ vs Control mice with intact YAP/TAZ (implied)
Design
Preclinical
Follow-up
Up to 14 days post-fracture
Authors
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Should not change clinical fracture management; leaves open YAP/TAZ as targets to enhance osteoblast-driven healing in translational models.
YAP and TAZ promote the expansion and differentiation of periosteal osteoblast precursors to accelerate bone fracture healing.
Peter W. Macfarlane (1998) studied this question.
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