Key result
Human papovavirus JC replicated efficiently in urine-derived epithelial cells, allowing for primary isolation from brain extracts and urine sediments of renal transplant patients.
Urine-derived epithelial cells can be used for the propagation and primary isolation of human papovavirus JC, particularly from urine sediments of renal transplant patients.
May aid JC virus isolation in transplant patients; leaves open clinical utility pending human validation.
Human papovavirus JC, previously passaged in amnion cells or in primary human fetal glial cells, replicated efficiently in urine-derived epithelial cells. Primary isolation of the virus from brain extracts was possible in urine-derived cells, but these cells were not as sensitive as primary human fetal glial cells for this purpose. Primary isolations of human papovavirus JC from urine sediments of renal transplant patients were made in urine-derived cells.
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Beckmann et al. (1982) studied Human papovavirus JC infection. Urine-derived epithelial cells vs. Primary human fetal glial cells was evaluated on Viral replication and primary isolation. Human papovavirus JC replicated efficiently in urine-derived epithelial cells, allowing for primary isolation from brain extracts and urine sediments of renal transplant patients.
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