Population
365 patients with diabetes (220 in cross-sectional study, 145 in cohort study) and cultured podocytes
Design
Cohort
Follow-up
7 years
Key result
Baseline serum ANGPTL2 levels were identified as an independent risk factor for the progression of diabetic kidney disease during a 7-year follow-up period.
Authors
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May aid DKD risk stratification in diabetes; hypothesis-generating and requires prospective validation before clinical use.
Observational (n=365)
Elevated serum ANGPTL2 is an independent risk factor for diabetic kidney disease progression and may directly cause podocyte dysfunction.
Ishii et al. (2018) conducted an observational in Diabetic kidney disease (n=365). Serum ANGPTL2 levels was evaluated on Progression of diabetic kidney disease. Baseline serum ANGPTL2 levels were identified as an independent risk factor for the progression of diabetic kidney disease during a 7-year follow-up period.