Why the study?
Is higher serum Angptl2 associated with an increased prevalence of chronic kidney disease in a general population?
Population
3,169 community-dwelling subjects aged ≥40 years (1,370 men, 1,799 women) from the Hisayama Study in Japan.
Comparison
Higher serum Angiopoietin-like protein 2 levels vs Lowest quintile of serum Angptl2 (<2.01 ng/ml)
Design
Cross-sectional
Key result
Elevated serum Angptl2 levels were significantly associated with an increased likelihood of chronic kidney disease, with the highest quintile showing an adjusted odds ratio of 1.79 compared to the lowest.
Authors
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Angptl2 should not yet inform CKD risk assessment; leaves open its value as progression biomarker or therapeutic target.
Cross-Sectional (n=3,169)
No
Is higher serum Angptl2 associated with an increased prevalence of chronic kidney disease in a general population?
Odds Ratio: 1.79 (95% CI 1.32–2.43)
p-value: p=0.001
Elevated serum Angptl2 levels are independently associated with a higher prevalence of chronic kidney disease, particularly albuminuria, in the general Japanese population.
Usui et al. (2013) conducted a cross-sectional in Chronic kidney disease (n=3,169). Serum Angiopoietin-like protein 2 (Angptl2) level vs. Lowest quintile of serum Angptl2 (<2.01 ng/ml) was evaluated on Presence of chronic kidney disease (albuminuria or decreased eGFR) (OR 1.79, 95% CI 1.32-2.43, p=0.001). Elevated serum Angptl2 levels were significantly associated with an increased likelihood of chronic kidney disease, with the highest quintile showing an adjusted odds ratio of 1.79 compared to the lowest.
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