Why the study?
Do elevated serum ANGPTL2 levels increase the risk of developing cardiovascular disease in a general population?
Population
3005 community-dwelling Japanese aged ≥40 years without a history of cardiovascular disease
Comparison
Highest quartile of serum ANGPTL2 concentrations vs Lowest quartile of serum ANGPTL2 concentrations
Design
Cohort
Follow-up
10 years
Key result
Elevated serum ANGPTL2 levels (highest vs lowest quartile) were significantly associated with an increased risk of developing cardiovascular disease (HR 1.66; 95% CI 1.05-2.60; P=0.02 for trend).
Authors
Loading...
Hypothesis-generating for ANGPTL2 in primary prevention; leaves open added value beyond traditional risk factors.
Cohort (n=3,005)
Do elevated serum ANGPTL2 levels increase the risk of developing cardiovascular disease in a general population?
Hazard Ratio: 1.66 (95% CI 1.05–2.6)
p-value: p=0.02 for trend
Elevated serum ANGPTL2 levels are a novel risk factor for the development of cardiovascular disease in the general population, partially mediated by metabolic disorders and inflammation.
Hata et al. (2016) conducted a cohort in Cardiovascular disease risk (n=3,005). Elevated serum ANGPTL2 concentrations vs. Lowest quartile of serum ANGPTL2 concentrations (Q1) was evaluated on Development of cardiovascular disease (coronary heart disease or stroke) (HR 1.66, 95% CI 1.05-2.60, p=0.02 for trend). Elevated serum ANGPTL2 levels (highest vs lowest quartile) were significantly associated with an increased risk of developing cardiovascular disease (HR 1.66; 95% CI 1.05-2.60; P=0.02 for trend).