What is the clinical evidence from this study?

Study design: Cohort. Population: General population (n=2912). Intervention: Serum ANGPTL2 concentrations. Primary outcome: all-cause mortality (HR 1.34, 95% CI 1.23-1.47).

What does this research mean for the field?

Elevated serum ANGPTL2 concentrations are significantly associated with a higher risk of all-cause and cause-specific mortality, including cardiovascular, cancer, and infectious disease deaths, in the general population. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research aims to explore the association between serum levels of ANGPTL2 and risk of cause-specific mortality in a general population.

May 24, 2026Journal of EpidemiologyOpen Access

Serum levels of angiopoietin-like protein 2 and the risk of cause-specific mortality in a general population: the Hisayama Study

View Full Paper

Ask AI

Bookmark

Why the study?

Few studies have investigated the relationship between circulating ANGPTL2 concentrations and cause-specific mortality risk in the general population.

Are elevated serum ANGPTL2 concentrations associated with an increased risk of all-cause and cause-specific mortality in a general population?

Population

2,912 community-dwelling Japanese adults aged ≥40 years without cardiovascular diseases or cancer

Comparison

Serum ANGPTL2 concentrations

Design

Prospective cohort study

Follow-up

Median of 15.2 years

Key result

Higher baseline serum ANGPTL2 concentrations were associated with an increased risk of all-cause mortality (HR 1.34; 95% CI 1.23-1.47 per 1-SD increment) over a median follow-up of 15.2 years.

Authors

JHJun Hata SSSatoko Sakata YFYoshihiko Furuta

Discussion

Member takes

Overview

May flag higher mortality risk in community adults; hypothesis-generating for ANGPTL2 in risk models.

Key Points

This research aims to explore the association between serum levels of ANGPTL2 and risk of cause-specific mortality in a general population.
Conducted a prospective cohort study with 2,912 Japanese adults aged ≥40 years.
Measured baseline serum ANGPTL2 concentrations from 2002–2003 and followed participants for a median of 15.2 years.
Used Cox proportional hazards models to estimate hazard ratios for mortality outcomes.
Higher serum ANGPTL2 levels corresponded to a HR of 1.34 (95% CI: 1.23–1.47) for all-cause mortality.
For cardiovascular death, HR was 1.28 (95% CI: 1.06–1.55); for cancer death, HR was 1.31 (95% CI: 1.12–1.53); and for infectious disease mortality, HR was 1.27 (95% CI: 1.05–1.54).
Associations were slightly reduced after adjustments for insulin resistance and chronic inflammation mediators.

Study Design

Type

Cohort (n=2,912)

Structured PICO

Are elevated serum ANGPTL2 concentrations associated with an increased risk of all-cause and cause-specific mortality in a general population?

Population

2,912 community-dwelling Japanese adults aged ≥40 years with no prior history of cardiovascular diseases or cancer.

Intervention

Higher baseline serum ANGPTL2 concentrations (collected in 2002–2003)

Comparator

Lower baseline serum ANGPTL2 concentrations

Outcome

All-cause and cause-specific mortality (cardiovascular death, cancer death, infectious diseases death, and other causes)hard clinical

Main Result

Effect estimate: HR 1.34 (95% CI 1.23-1.47)

Elevated serum ANGPTL2 concentrations are an independent risk factor for all-cause and cause-specific mortality, including cardiovascular death, in the general population.

Cite This Study

Hata et al. (2026) conducted a cohort in General population (n=2,912). Serum ANGPTL2 concentrations was evaluated on all-cause mortality (HR 1.34, 95% CI 1.23-1.47). Higher baseline serum ANGPTL2 concentrations were associated with an increased risk of all-cause mortality (HR 1.34; 95% CI 1.23-1.47 per 1-SD increment) over a median follow-up of 15.2 years.

synapsesocial.com/papers/6a129af248a0ea1665674094 https://doi.org/10.2188/jea.je20250491

View Full Paper

Ask AI

Bookmark

May 24, 2026Journal of EpidemiologyOpen Access

Serum levels of angiopoietin-like protein 2 and the risk of cause-specific mortality in a general population: the Hisayama Study

View Full Paper

Ask AI

Bookmark

Why the study?

Few studies have investigated the relationship between circulating ANGPTL2 concentrations and cause-specific mortality risk in the general population.

Are elevated serum ANGPTL2 concentrations associated with an increased risk of all-cause and cause-specific mortality in a general population?

Population

2,912 community-dwelling Japanese adults aged ≥40 years without cardiovascular diseases or cancer

Comparison

Serum ANGPTL2 concentrations

Design

Prospective cohort study

Follow-up

Median of 15.2 years

Key result

Higher baseline serum ANGPTL2 concentrations were associated with an increased risk of all-cause mortality (HR 1.34; 95% CI 1.23-1.47 per 1-SD increment) over a median follow-up of 15.2 years.

Authors

JHJun Hata SSSatoko Sakata YFYoshihiko Furuta

Discussion

Member takes

Overview

May flag higher mortality risk in community adults; hypothesis-generating for ANGPTL2 in risk models.

Key Points

This research aims to explore the association between serum levels of ANGPTL2 and risk of cause-specific mortality in a general population.
Conducted a prospective cohort study with 2,912 Japanese adults aged ≥40 years.
Measured baseline serum ANGPTL2 concentrations from 2002–2003 and followed participants for a median of 15.2 years.
Used Cox proportional hazards models to estimate hazard ratios for mortality outcomes.
Higher serum ANGPTL2 levels corresponded to a HR of 1.34 (95% CI: 1.23–1.47) for all-cause mortality.
For cardiovascular death, HR was 1.28 (95% CI: 1.06–1.55); for cancer death, HR was 1.31 (95% CI: 1.12–1.53); and for infectious disease mortality, HR was 1.27 (95% CI: 1.05–1.54).
Associations were slightly reduced after adjustments for insulin resistance and chronic inflammation mediators.

Study Design

Type

Cohort (n=2,912)

Structured PICO

Are elevated serum ANGPTL2 concentrations associated with an increased risk of all-cause and cause-specific mortality in a general population?

Population

2,912 community-dwelling Japanese adults aged ≥40 years with no prior history of cardiovascular diseases or cancer.

Intervention

Higher baseline serum ANGPTL2 concentrations (collected in 2002–2003)

Comparator

Lower baseline serum ANGPTL2 concentrations

Outcome

All-cause and cause-specific mortality (cardiovascular death, cancer death, infectious diseases death, and other causes)hard clinical

Main Result

Effect estimate: HR 1.34 (95% CI 1.23-1.47)

Elevated serum ANGPTL2 concentrations are an independent risk factor for all-cause and cause-specific mortality, including cardiovascular death, in the general population.

Cite This Study

synapsesocial.com/papers/6a129af248a0ea1665674094 https://doi.org/10.2188/jea.je20250491

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

View Full Paper

Ask AI

Bookmark