Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 30, 2013European Journal of Heart FailureOpen Access

Circulating Angiopoietin-2, Its Soluble Receptor Tie-2, and Mortality in the General Population

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Are circulating concentrations of Ang-2 and sTie-2 associated with all-cause, cardiovascular, and cancer mortality in the general population?

Population

3220 participants from the general population (Study of Health in Pomerania), mean age 54.4 years, 1665 women.

Design

Cohort

Follow-up

median 6.2 years

Authors

RLRoberto LorbeerLMU KlinikumSBSebastian E. BaumeisterUniversity of AugsburgMDMarcus DörrGeneral / Preventive / Lipids

Discussion

Loading...

Member takes

Overview

Ang-2 may refine mortality risk stratification in unselected adults; extends observational biomarker data but leaves incremental utility open.

Key Points

  • To evaluate the relationship between circulating angiopoietin-2 and its soluble receptor Tie-2 concentrations with all-cause, cardiovascular, and cancer mortality in the general population.
  • Assessed 3,220 participants (1,665 women; mean age 54.4 years) from the Study of Health in Pomerania over a median follow-up of 6.2 years (217 deaths).
  • Estimated multivariable-adjusted hazard ratios for mortality endpoints using Cox proportional hazard models and evaluated risk discrimination using Harrell's C and net reclassification improvement.
  • Angiopoietin-2 levels were significantly associated with all-cause mortality (HR 1.29; 95% CI 1.19–1.39 per 1 SD increment; P < 0.001) and cardiovascular mortality (HR 1.32; 95% CI 1.18–1.49; P < 0.001), but not cancer mortality (HR 1.08; 95% CI 0.89–1.32; P = 0.416).
  • Soluble Tie-2 levels showed no significant association with all-cause mortality (HR 1.12; 95% CI 0.98–1.27; P = 0.102).
  • Adding angiopoietin-2 to standard risk factor models yielded a minor improvement in discrimination (Δ Harrell's C 0.008; P < 0.001) but did not improve continuous net reclassification (-0.015; P = 0.571).

Structured PICO

Are circulating concentrations of Ang-2 and sTie-2 associated with all-cause, cardiovascular, and cancer mortality in the general population?

P
Population
3220 participants from the general population (Study of Health in Pomerania), mean age 54.4 years, 1665 women.
I
Intervention
Circulating concentrations of angiopoietin-2 (Ang-2) and its soluble receptor Tie-2 (sTie-2)
O
Outcome
All-cause, cardiovascular, and cancer mortalityhard clinical

Higher serum Ang-2 concentrations are associated with greater risk for all-cause and cardiovascular mortality in the general population, though adding it to prediction models only modestly improves discrimination.

Cite This Study

Lorbeer et al. (2013) studied this question.

synapsesocial.com/papers/6a70812c35aa2c282ce1d3cbhttps://doi.org/10.1093/eurjhf/hft117
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Plasma Vascular Endothelial Growth Factor, Angiopoietin-1, and Angiopoietin-2 in Diabetes2004 · 159 citations
  2. 2Endothelial Dysfunction, Measured by Reactive Hyperaemia Using Strain-Gauge Plethysmography, is an Independent Predictor of Adverse Outcome in Heart Failure2010 · 58 citations
  3. 3Angiopoietin-2 levels predict mortality in CKD patients2011 · 84 citations
  4. 4Excess circulating angiopoietin-2 is a strong predictor of mortality in critically ill medical patients2008 · 169 citations
  5. 5Angiopoietin‐2 expression in breast cancer correlates with lymph node invasion and short survival2002 · 201 citations