What question did this study set out to answer?

To examine the relationship between circulating levels of angiopoietin-2 and its soluble receptor Tie-2 with subclinical structural and functional markers of cardiovascular disease.

October 6, 2014Heart

Angiopoietin-2, its soluble receptor Tie-2 and subclinical cardiovascular disease in a population-based sample

View Full Paper

Ask AI

Bookmark

Why the study?

Are circulating Ang-2 and sTie-2 levels associated with subclinical cardiovascular disease in a population-based sample?

Population

3,204 participants (1,654 women) aged 25-88 years from the population-based Study of Health in Pomerania.

Design

Cross-sectional

Authors

RLRoberto LorbeerLMU Klinikum SBSebastian E. BaumeisterUniversity of Augsburg MDMarcus DörrGeneral / Preventive / Lipids

Discussion

Member takes

Implication

Ang-2 may mark subclinical cardiac and vascular changes; hypothesis-generating and leaves open causality or therapeutic targeting.

Key Points

To examine the relationship between circulating levels of angiopoietin-2 and its soluble receptor Tie-2 with subclinical structural and functional markers of cardiovascular disease.
Analyzed cross-sectional data from 3,204 participants (1,654 women) aged 25–88 years in the population-based Study of Health in Pomerania.
Assessed cardiac structure and function using echocardiographic left ventricular mass and fractional shortening, and arterial health using carotid intima-media thickness, carotid plaque count, and flow-mediated dilation.
Evaluated associations using multivariable-adjusted linear and negative binomial regression models.
Circulating Ang-2 was inversely associated with fractional shortening (ß = -0.51 per 1 SD increment; 95% CI -0.86 to -0.16, p = 0.005).
Circulating Ang-2 was positively associated with carotid plaque count (rate ratio = 1.04; 95% CI 1.01 to 1.07, p = 0.019).
No significant associations were observed between Ang-2 or sTie-2 and left ventricular mass, carotid intima-media thickness, or flow-mediated dilation.

Structured PICO

Are circulating Ang-2 and sTie-2 levels associated with subclinical cardiovascular disease in a population-based sample?

Population

3,204 participants (1,654 women) aged 25-88 years from the population-based Study of Health in Pomerania.

Intervention

Circulating Angiopoietin-2 (Ang-2) and sTie-2 levels (exposure)

Outcome

Subclinical cardiovascular disease measures including LV mass, fractional shortening, carotid intima media thickness, number of carotid plaques, and flow-mediated dilationsurrogate

Higher circulating Ang-2 levels are associated with reduced fractional shortening and increased carotid plaques, suggesting a role in mediating subclinical cardiovascular morbidity.

Cite This Study

Lorbeer et al. (2014) studied this question.

synapsesocial.com/papers/6a70812c35aa2c282ce1d3c9 https://doi.org/10.1136/heartjnl-2014-306056

Topics

Women and heart disease Echocardiography

View Full Paper

Ask AI

Bookmark

Angiopoietin-2, its soluble receptor Tie-2 and subclinical cardiovascular disease in a population-based sample

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Angiopoietin-2, its soluble receptor Tie-2 and subclinical cardiovascular disease in a population-based sample

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider