Clinical and Genetic Correlates of Circulating Angiopoietin-2 and Soluble Tie-2 in the Community
Key result
Circulating levels of Ang-2 and sTie-2 are heritable traits (27% and 56%, respectively; P<0.0001) associated with cardiovascular disease risk factors, including metabolic syndrome.
Population
3778 third-generation cohort participants of the Framingham Heart Study (mean age, 40+/-9 years; 53% women)
Design
Cohort
Authors
Discussion
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Member takes
Implication
Heritability of Ang-2/sTie-2 supports genetic studies of vascular pathways; leaves open causal or predictive roles in metabolic syndrome.
Study Design
Type
Cohort (n=3,778)
Structured PICO
P
Population
3,778 third-generation cohort participants of the Framingham Heart Study (mean age 40 years, 53% women) assessed for clinical and genetic correlates of circulating Ang-2 and sTie-2.
O
Outcome
Clinical correlates and heritability of circulating angiopoietin-2 (Ang-2) and soluble Tie-2 (sTie-2)surrogate
Main Result
p-value: p=<0.0001
Circulating levels of Ang-2 and sTie-2 are heritable traits that are significantly associated with cardiovascular disease risk factors, including metabolic syndrome.
Cite This Study
Lieb et al. (2010) conducted a cohort in General population (n=3,778). Circulating angiopoietin-2 (Ang-2) and soluble Tie-2 (sTie-2) was evaluated on Clinical correlates and heritability of Ang-2 and sTie-2 (p=<0.0001). Circulating levels of Ang-2 and sTie-2 are heritable traits (27% and 56%, respectively; P<0.0001) associated with cardiovascular disease risk factors, including metabolic syndrome.