Why the study?
Do elevated serum ANGPTL2 levels predict mortality in patients with heart failure?
Population
303 patients with heart failure
Comparison
Elevated serum ANGPTL2 levels (highest tertile) vs Lowest tertile of serum ANGPTL2 levels
Design
Cohort
Follow-up
5 years
Key result
Elevated serum ANGPTL2 levels (highest vs lowest tertile) were significantly associated with increased all-cause mortality in patients with heart failure (adjusted HR 1.91; 95% CI 1.13-3.23; p=0.015).
Authors
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May enhance mortality risk stratification in heart failure; leaves open incremental value and causal role pending prospective validation.
Cohort (n=303)
Do elevated serum ANGPTL2 levels predict mortality in patients with heart failure?
Hazard Ratio: 1.91 (95% CI 1.13–3.23)
p-value: p=0.015
Elevated circulating ANGPTL2 is an independent predictor of all-cause mortality in patients with heart failure, improving risk stratification beyond traditional factors.
Brandtner et al. (2025) conducted a cohort in Heart failure (n=303). Serum ANGPTL2 levels (highest tertile) vs. Lowest tertile of ANGPTL2 levels was evaluated on All-cause mortality (HR 1.91, 95% CI 1.13-3.23, p=0.015). Elevated serum ANGPTL2 levels (highest vs lowest tertile) were significantly associated with increased all-cause mortality in patients with heart failure (adjusted HR 1.91; 95% CI 1.13-3.23; p=0.015).