Why the study?
Patients receiving hemodialysis have a poor prognosis often driven by premature aging phenotypes and systemic inflammation, but whether ANGPTL2 is associated with increased mortality risk in this population was unknown.
Are circulating ANGPTL2 levels associated with increased mortality risk in patients receiving maintenance hemodialysis?
Population
412 patients receiving maintenance hemodialysis
Comparison
Circulating ANGPTL2 levels analyzed as a continuous variable
Design
Multicenter prospective cohort study
Key result
High circulating ANGPTL2 levels were associated with an increased risk of all-cause mortality in patients receiving maintenance hemodialysis (HR 2.04; 95% CI 1.10-3.77).
Authors
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May aid risk stratification in hemodialysis; hypothesis-generating and requires prospective validation before any clinical use.
Cohort (n=412)
Yes
Are circulating ANGPTL2 levels associated with increased mortality risk in patients receiving maintenance hemodialysis?
Hazard Ratio: 2.04 (95% CI 1.1–3.77)
Circulating ANGPTL2 levels are positively associated with mortality risk in patients receiving maintenance hemodialysis, potentially serving as a marker for premature aging and subsequent mortality.
Morinaga et al. (2019) conducted a cohort in Maintenance hemodialysis (n=412). High circulating ANGPTL2 levels was evaluated on All-cause mortality (HR 2.04, 95% CI 1.10-3.77). High circulating ANGPTL2 levels were associated with an increased risk of all-cause mortality in patients receiving maintenance hemodialysis (HR 2.04; 95% CI 1.10-3.77).