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November 16, 2018Journal of Translational MedicineOpen Access

Association of serum angiopoietin-2 with malnutrition, inflammation, atherosclerosis and valvular calcification syndrome and outcome in peritoneal dialysis patients: a prospective cohort study

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Why the study?

The study was conducted to examine serum angiopoietin-2 in relation to MIAC syndrome and its predictive role in outcomes of peritoneal dialysis patients.

Population

324 chronic peritoneal dialysis patients

Comparison

Serum angiopoietin-2 levels across tertiles

Design

Prospective observational study

Authors

XYXiaoxiao YangHZHe ZhangYSYuanyuan Shi

Discussion

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Overview

Angpt-2 may refine CV risk stratification in PD; hypothesis-generating and requires prospective validation before clinical use.

Structured PICO

P
Population
324 chronic peritoneal dialysis (PD) patients, mean age 57.4, 51% male, single-center in China. Exclusions: acute coronary syndrome, acute heart failure, peritonitis, exit-site infection, active malignancy, chronic liver disease, systemic lupus erythematosus, systemic vasculitis, chronic rheumatic heart disease, congenital heart disease, and systemic inflammatory disease.
I
Intervention
Elevated serum angiopoietin-2 (Angpt-2) levels (stratified into tertiles)
C
Comparator
Lower tertiles of serum Angpt-2
O
Outcome
Fatal or nonfatal cardiovascular events and all-cause mortalityhard clinical

Elevated serum Angpt-2 is an independent predictor of fatal and nonfatal cardiovascular events in patients undergoing peritoneal dialysis, suggesting its utility for cardiovascular risk stratification.

Cite This Study

Yang et al. (2018) studied this question.

synapsesocial.com/papers/6a89c9461fb56efa37d46f0dhttps://doi.org/10.1186/s12967-018-1687-0
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Plasma Angiopoietin-1, Angiopoietin-2, Angiopoietin Receptor Tie-2, and Vascular Endothelial Growth Factor Levels in Acute Coronary Syndromes2004 · 189 citations
  2. 2Angiopoietin-2 in Adults with Congenital Heart Disease and Heart Failure2013 · 29 citations
  3. 3Cardiac Valve Calcification as an Important Predictor for All-Cause Mortality and Cardiovascular Mortality in Long-Term Peritoneal Dialysis Patients2003 · 395 citations
  4. 4High Glucose Increases Angiopoietin-2 Transcription in Microvascular Endothelial Cells through Methylglyoxal Modification of mSin3A2007 · 234 citations
  5. 5Heart Disease: A Textbook of Cardiovascular Medicine1997 · 1,074 citations