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September 11, 2012Diabetes CareOpen Access

Angiopoietin-Like Protein 2 and Risk of Type 2 Diabetes in a General Japanese Population

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Why the study?

Does elevated serum ANGPTL2 increase the risk of developing type 2 diabetes in community-dwelling adults without diabetes?

Population

2,164 community-dwelling Japanese individuals aged 40 to 79 years without diabetes

Comparison

Highest quartile of serum ANGPTL2 levels vs Lowest quartile of serum ANGPTL2 levels

Design

Cohort

Follow-up

7 years

Authors

YDYasufumi DoiTNToshiharu NinomiyaYHYoichiro Hirakawa

Discussion

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Member takes

Overview

May refine T2DM risk assessment in community adults; extends observational data but leaves causality and intervention open.

Structured PICO

Does elevated serum ANGPTL2 increase the risk of developing type 2 diabetes in community-dwelling adults without diabetes?

P
Population
2,164 community-dwelling Japanese individuals aged 40 to 79 years without diabetes
I
Intervention
Highest quartile of serum ANGPTL2 levels (≥3.41 ng/mL)
C
Comparator
Lowest quartile of serum ANGPTL2 levels (<2.15 ng/mL)
O
Outcome
Development of type 2 diabetes (T2DM) over 7 years

Elevated serum ANGPTL2 levels are an independent risk factor for the development of type 2 diabetes in a general Japanese population.

Cite This Study

Doi et al. (2012) studied this question.

synapsesocial.com/papers/6a7d06fe8253d2b4939ff9fahttps://doi.org/10.2337/dc12-0166
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Serum Angiopoietin–Like Protein 2 Is a Novel Risk Factor for Cardiovascular Disease in the Community2016 · 40 citations
  2. 2Serum levels of angiopoietin-like protein 2 and the risk of cause-specific mortality in a general population: the Hisayama Study2026
  3. 3Angiopoietin-Like Protein 2 Is Associated With Chronic Kidney Disease in a General Japanese Population2013 · 35 citations
  4. 4Association of serum angiopoietin-like protein 2 with carotid intima-media thickness in subjects with type 2 diabetes2015 · 19 citations
  5. 5Angiopoietin-Like Protein 2 Promotes the Progression of Diabetic Kidney Disease2018 · 18 citations