Why the study?
Does kidney transplantation reduce ANGPTL2 levels, and are post-transplantation levels associated with aortic stiffness and mortality in patients with chronic kidney disease?
Population
75 patients undergoing kidney transplantation
Comparison
Kidney transplantation vs Pre-transplantation baseline
Design
Cohort
Follow-up
median 90 months
Key result
Higher post-kidney transplantation ANGPTL2 levels were associated with a significantly increased risk of mortality (HR 3.9; 95% CI 1.07-14.4; P=0.039).
Authors
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May stratify post-transplant mortality risk; leaves open ANGPTL2 as a modifiable target in CKD.
Cohort (n=75)
Does kidney transplantation reduce ANGPTL2 levels, and are post-transplantation levels associated with aortic stiffness and mortality in patients with chronic kidney disease?
Hazard Ratio: 3.9 (95% CI 1.07–14.4)
p-value: p=0.039
Kidney transplantation significantly reduces serum ANGPTL2 levels, and higher residual levels are associated with increased aortic stiffness and long-term mortality.
Desjardins et al. (2017) conducted a cohort in Kidney transplantation (n=75). Higher post-KTx ANGPTL2 levels vs. Lower post-KTx ANGPTL2 levels was evaluated on Mortality (HR 3.9, 95% CI 1.07-14.4, p=0.039). Higher post-kidney transplantation ANGPTL2 levels were associated with a significantly increased risk of mortality (HR 3.9; 95% CI 1.07-14.4; P=0.039).