Key result
Conservative treatment with anticoagulation and antiplatelet therapy resulted in complete dissolution of an ascending aortic thrombus and resolution of myocardial infarction symptoms in a patient who refused surgery.
Why the study?
Ascending aortic thrombosis is extremely rare with an unclear pathogenesis, and clinical manifestations depend on the site of embolism caused by thrombus dislodgement.
Case Report (n=1)
No
Conservative medical therapy with anticoagulation and antiplatelets can successfully dissolve ascending aortic thrombus in patients who refuse surgery, though it carries a risk of embolic events such as myocardial infarction.
May offer alternative for surgery-refusing patients; extends sparse case data but leaves open safety and generalizability.
Background: Ascending aortic thrombosis is extremely rare and its pathogenesis is unclear. Clinical manifestations are often related to the site of embolism caused by thrombus dislodgement. Currently, surgery is considered the first choice to prevent embolism and recurrence, while medical therapy is an option for patients who refuse surgery or for whom surgery is contraindicated.
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Haixia Xu (2023) conducted a case report in Myocardial infarction due to ascending aortic thrombosis (n=1). Conservative treatment (aspirin, clopidogrel, heparin) was evaluated on Thrombus dissolution. Conservative treatment with anticoagulation and antiplatelet therapy resulted in complete dissolution of an ascending aortic thrombus and resolution of myocardial infarction symptoms in a patient who refused surgery.
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