Key result
Proatherogenic adhesion molecules and inflammatory cytokines were elevated in patients with type 2 diabetes mellitus, contributing to accelerated atherogenesis.
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Elevated levels of specific adhesion molecules and inflammatory cytokines in type 2 diabetes contribute to accelerated atherogenesis, highlighting their potential as targets for reducing cardiovascular complications.
The aim of this review was to analyze the main biomarkers of vascular function and impairment in patients with type 2 diabetes. Medline, SCOPUS, Web of Science, and Google Scholar databases were searched. We concluded that proatherogenic adhesion molecules (soluble intercellular adhesion molecule-1, soluble vascular adhesion molecule-1, and soluble E selectin) and inflammatory cytokines (high-sensitivity C-reactive protein, interleukin-6, and tumor necrosis factor-α) were elevated in type 2 diabetes mellitus. Their increased expression and release contribute to the accelerated atherogenesis typical of these patients. For these reasons, the early identification of high levels of these biomarkers will help to establish new strategies to reduce cardiovascular complications.
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Derosa et al. (2016) conducted a review in type 2 diabetes mellitus. Proatherogenic adhesion molecules and inflammatory cytokines was evaluated on Vascular function and impairment. Proatherogenic adhesion molecules and inflammatory cytokines were elevated in patients with type 2 diabetes mellitus, contributing to accelerated atherogenesis.
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