Key result
Genghis Khan (Gek) is a multidomain protein kinase that binds to Drosophila Cdc42 in a GTP-dependent manner and is required for proper actin polymerization and oogenesis in vivo.
The multidomain protein kinase Genghis Khan (Gek) is identified as an effector for Drosophila Cdc42 that regulates actin polymerization and is essential for proper oogenesis.
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Findings in Drosophila warrant clinical caution; extends Cdc42 signaling map but leaves open mammalian conservation.
Luo et al. (1997) studied Actin polymerization and oogenesis defects. gek mutations vs. wild-type was evaluated on F-actin accumulation and egg fertilization. Genghis Khan (Gek) is a multidomain protein kinase that binds to Drosophila Cdc42 in a GTP-dependent manner and is required for proper actin polymerization and oogenesis in vivo.