Key result
Reintroducing both canonically translated and frameshifted PLEKHM2 proteins restored normal contractile function in knockout cardiomyocytes, demonstrating its necessity for normal cardiac activity.
Why the study?
Very few phylogenetically conserved examples of programmed ribosomal frameshifting are known in nuclear-encoded genes.
Does reintroducing both canonically translated and frameshifted PLEKHM2 protein restore normal contractile function in PLEKHM2 knockout cardiomyocytes?
Population
PLEKHM2 knockout cardiomyocytes
Comparison
Reintroducing both canonically translated and frameshifted protein vs knockout
Design
Preclinical laboratory study
Authors
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May inform PLEKHM2 function in cardiac disease; leaves open its therapeutic relevance pending validation.
Does reintroducing both canonically translated and frameshifted PLEKHM2 protein restore normal contractile function in PLEKHM2 knockout cardiomyocytes?
Programmed ribosomal frameshifting in the human gene PLEKHM2 generates a constitutively active proteoform that is essential for normal cardiomyocyte contractile function.
Loughran et al. (2025) studied Myocardial function. Reintroducing canonically translated and frameshifted PLEKHM2 protein vs. PLEKHM2 knockout cardiomyocytes was evaluated on Restoration of normal contractile function. Reintroducing both canonically translated and frameshifted PLEKHM2 proteins restored normal contractile function in knockout cardiomyocytes, demonstrating its necessity for normal cardiac activity.
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