What question did this study set out to answer?

To identify the upstream regulatory mechanisms that control Arl8b- and BORC-dependent lysosomal movement toward the cellular periphery.

October 9, 2017The Journal of Cell BiologyOpen Access

LAMTOR/Ragulator is a negative regulator of Arl8b- and BORC-dependent late endosomal positioning

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Authors

PFPrzemyslaw A. FilipekAustrian Drug Screening Institute (Austria)MAMariana E. G. de AraújoInnsbruck Medical University GVGeorg F. VogelInnsbruck Medical University

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Implication

Mechanistic study reveals LAMTOR-mediated suppression of peripheral lysosomal motility in human cells, indicating growth signals dynamically drive organelle transport.

Key Points

To identify the upstream regulatory mechanisms that control Arl8b- and BORC-dependent lysosomal movement toward the cellular periphery.
Analyzed structural interactions between BORC subunits, Arl8b, and the LAMTOR/Ragulator complex during late endosomal positioning.
Evaluated the impact of lyspersin domain truncations and epidermal growth factor stimulation on LAMTOR/BORC complex assembly and organelle motility.
The C-terminal domain of lyspersin was found to be essential and sufficient for BORC-dependent recruitment of Arl8b to lysosomes.
Lyspersin directly links the BORC complex with the LAMTOR adaptor complex.
Epidermal growth factor stimulation decreased the physical association between LAMTOR and BORC, accelerating BORC- and Arl8b-dependent centrifugal transport of lysosomes.

Cite This Study

Filipek et al. (2017) studied this question.

synapsesocial.com/papers/6aaf93f5f6bf3b8571de7226 https://doi.org/10.1083/jcb.201703061

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Implication

Mechanistic study reveals LAMTOR-mediated suppression of peripheral lysosomal motility in human cells, indicating growth signals dynamically drive organelle transport.

LAMTOR/Ragulator is a negative regulator of Arl8b- and BORC-dependent late endosomal positioning

Discussion

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Implication

Key Points

Cite This Study

LAMTOR/Ragulator is a negative regulator of Arl8b- and BORC-dependent late endosomal positioning

Discussion

Member takes

Implication

Key Points

Cite This Study

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