Key result
N-isopropylacrylamide and κ-carrageenan semi-IPN hydrogels exhibited pH- and temperature-dependent swelling, with maximum swelling around 30°C and water transport changing from Fickian to anomalous.
The study demonstrates that N-isopropylacrylamide and κ-carrageenan semi-IPN hydrogels exhibit pH- and temperature-dependent swelling behavior, with water transport mechanisms shifting from Fickian to anomalous diffusion.
Merits evaluation for controlled release in cardiac applications; leaves open clinical adoption due to animal-only evidence.
Semi-IPN formation has been achieved in a system comprising N-isopropylacrylamide and κ-carrageenan by an electron beam irradiation technique. The conditions for obtaining mechanically stable gels have been optimized. The gels were characterized by DSC, SEM, and FTIR techniques. Dynamic swelling measurements were carried out under different pH and temperature conditions. The results revealed the structure, pH, and temperature-dependent swelling behavior of the gels. The % swelling (S) of the hydrogels at various pH followed the order 9.0 < 1.2 <4.0 < 7.0. Also, the gels exhibited temperature dependence, with swelling being highest around 30°C. The “n” values for these hydrogels were in the range 0.31–0.79, indicating that the mechanism of water transport changes from Fickian to anomalous diffusion, with change in the network structure of the gel matrix.
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Athira Mohanan (2011) studied this question. N-isopropylacrylamide and κ-carrageenan semi-IPN hydrogels was evaluated on Swelling and diffusion characteristics. N-isopropylacrylamide and κ-carrageenan semi-IPN hydrogels exhibited pH- and temperature-dependent swelling, with maximum swelling around 30°C and water transport changing from Fickian to anomalous.
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