Key result
The ANGPT2 genetic variant rs1868554 was significantly associated with an increased risk of trauma-associated acute lung injury (OR 1.22) and an altered plasma angiopoietin-2 isoform ratio.
Why the study?
Are ANGPT2 genetic variants associated with acute lung injury after major trauma?
Case-Control (n=3,088)
Yes
Are ANGPT2 genetic variants associated with acute lung injury after major trauma?
Odds Ratio: 1.22 (95% CI 1.06–1.4)
p-value: p=0.0047
Genetic variants in the ANGPT2 region are associated with trauma-associated acute lung injury and altered plasma angiopoietin-2 isoform ratios, providing insights into ALI susceptibility.
No takes yet. Share an insight, caveat, or question.
ANGPT2 variant testing should not yet guide trauma care; extends ALI susceptibility insights but requires prospective validation.
Meyer et al. (2011) conducted a case-control in Trauma-associated Acute Lung Injury (n=3,088). ANGPT2 genetic variant rs1868554 vs. Reference genotype was evaluated on Development of acute lung injury (OR 1.22, 95% CI 1.06-1.40, p=0.0047). The ANGPT2 genetic variant rs1868554 was significantly associated with an increased risk of trauma-associated acute lung injury (OR 1.22) and an altered plasma angiopoietin-2 isoform ratio.
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