Key result
Fentanyl premedication at 0.5 µg/kg and 1 µg/kg significantly reduced maternal mean arterial pressure at 1 minute after intubation compared to saline control (106.2 and 103.33 vs 112.73 mmHg, p<0.01).
Why the study?
Does low-dose fentanyl prevent hemodynamic changes during induction and intubation in parturients undergoing caesarean section under general anesthesia?
RCT (n=45)
Double-blind
Blocked randomization
No
Does low-dose fentanyl prevent hemodynamic changes during induction and intubation in parturients undergoing caesarean section under general anesthesia?
Fentanyl at a low dose of 0.5 µg/kg effectively blunts the maternal hemodynamic stress response to intubation during caesarean section without causing adverse fetal effects.
Answers are grounded in this paper and cite their sources.
Supports low-dose fentanyl to blunt intubation response in GA caesarean; extends hemodynamic data to parturients.
Introduction: Present study was designed to find low, safe and efficacious dose of fentanyl to avoid its foetal side effects by comparing two doses of fentanyl to prevent haemodynamic hazards at induction and intubation in patients undergoing caesarean section (CS) under general anaesthesia (GA).Method: Forty five full term parturients posted for emergency/elective caesarean section under GA of ASA Grade I or II, age group between 18 to 35 years were randomly distributed into three groups. Intravenous fentanyl 0.5µg/kg or1µg/kg diluted to 5 ml or normal saline 5 ml was administered three minutes before induction in Group F 0.5, Group F1or Group C respectively. Maternal haemodynamic parameters and foetal parameters were recorded at different time intervals.Results: Group F and Group F1 showed significant reduction and stability in maternal haemodynamics when compared with the control group, but no statistical difference was observed amongst them. No difference was observed in foetal Apgar score and cord blood pH in all three groups.Conclusion: Fentanyl in doses as low as 0.5µg/kg can be used safely in parturients to prevent haemodynamic hazards at intubation in patients undergoing CS under GA.
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Deogaonkar et al. (2016) conducted an RCT in Parturients undergoing caesarean section under general anesthesia (n=45). Fentanyl vs. Normal saline was evaluated on Mean Arterial Pressure (MAP) at 1 min after intubation (p=<0.01). Fentanyl premedication at 0.5 µg/kg and 1 µg/kg significantly reduced maternal mean arterial pressure at 1 minute after intubation compared to saline control (106.2 and 103.33 vs 112.73 mmHg, p<0.01).
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