Key result
Fentanyl 5 μg/kg was significantly more effective than 2.5 μg/kg in attenuating the blood pressure response and lowering the rate pressure product during laryngoscopy and intubation.
Why the study?
Laryngoscopy and tracheal intubation trigger tachycardia and hypertension that may be hazardous in patients with myocardial insufficiency or cerebrovascular disease, warranting evaluation of strategies to attenuate this hemodynamic stress response.
Does fentanyl 5 μg/kg compared to 2.5 μg/kg improve hemodynamic stability during laryngoscopy and intubation in adult patients undergoing elective surgery?
RCT (n=60)
Randomly allocated
Does fentanyl 5 μg/kg compared to 2.5 μg/kg improve hemodynamic stability during laryngoscopy and intubation in adult patients undergoing elective surgery?
A 5 μg/kg dose of fentanyl is more effective than a 2.5 μg/kg dose in attenuating the blood pressure response and myocardial oxygen consumption during endotracheal intubation.
No takes yet. Share an insight, caveat, or question.
Fentanyl dosing for intubation hemodynamics needs validation; leaves open optimal regimen in high-risk patients.
Patel et al. (2022) conducted an RCT in Elective surgery under general anaesthesia requiring endotracheal intubation (n=60). Fentanyl vs. Fentanyl 2.5 μg/kg intravenously was evaluated on Haemodynamic stress response (pulse rate, blood pressure, rate pressure product). Fentanyl 5 μg/kg was significantly more effective than 2.5 μg/kg in attenuating the blood pressure response and lowering the rate pressure product during laryngoscopy and intubation.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: