What question did this study set out to answer?

To evaluate the clinical features and potential association between HIV-1 protease inhibitor treatment and the development of coronary heart disease.

October 1, 2001Clinical CardiologyOpen Access

Coronary heart disease associated with the use of human immunodeficiency virus (HTV)‐1 protease inhibitors: Report of four cases and review

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To evaluate the clinical features and potential association between HIV-1 protease inhibitor treatment and the development of coronary heart disease.
Reported 4 cases of HIV-infected patients who developed coronary heart disease while receiving protease inhibitor therapy.
Analyzed epidemiological and clinical characteristics of 18 previously reported literature cases.
Myocardial infarction was the predominant cardiac manifestation, with smoking (72%) and hyperlipidemia (81%) identified as the most prevalent risk factors.
Hypercholesterolemia was documented in 75% of cases at the time of the cardiac event, and 90% of patients with normal baseline lipid levels developed elevated lipids during protease inhibitor treatment.

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Implication

Case series and literature review observes frequent myocardial infarction and hyperlipidemia in HIV patients receiving protease inhibitors, suggesting treatment-induced lipids accelerate...

Cite This Study

Duong et al. (2001) studied this question.

synapsesocial.com/papers/6a9ecf796e3e9028e6be7191 https://doi.org/10.1002/clc.4960241011

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Implication

Case series and literature review observes frequent myocardial infarction and hyperlipidemia in HIV patients receiving protease inhibitors, suggesting treatment-induced lipids accelerate...

Coronary heart disease associated with the use of human immunodeficiency virus (HTV)‐1 protease inhibitors: Report of four cases and review

Key Points

Discussion

Implication

Cite This Study

Coronary heart disease associated with the use of human immunodeficiency virus (HTV)‐1 protease inhibitors: Report of four cases and review

Key Points

Discussion

Implication

Cite This Study

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