Key result
Genetic ablation of TbZFP1 in Trypanosoma brucei compromised the repositioning of the mitochondrial genome during differentiation, demonstrating that programmed developmental events can be uncoupled.
This study demonstrates that programmed events in T. brucei development can be uncoupled at the molecular level by ablating TbZFP1.
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Hypothesis-generating for disrupting T. brucei differentiation; leaves open therapeutic translation in trypanosomiasis.
Hendriks et al. (2005) studied Trypanosoma brucei parasite development. Genetic ablation of TbZFP1 was evaluated on Repositioning of the mitochondrial genome during differentiation. Genetic ablation of TbZFP1 in Trypanosoma brucei compromised the repositioning of the mitochondrial genome during differentiation, demonstrating that programmed developmental events can be uncoupled.
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