Key result
Assessment of the humoral response to the Trypanosoma cruzi 160-kDa complement regulatory protein is a useful indicator of parasite clearance in patients with Chagas' disease.
Why the study?
Does the humoral immune response to the Trypanosoma cruzi 160-kDa complement regulatory protein indicate parasitologic clearance in human Chagas' disease?
Observational
Does the humoral immune response to the Trypanosoma cruzi 160-kDa complement regulatory protein indicate parasitologic clearance in human Chagas' disease?
The humoral response to the T. cruzi 160-kDa complement regulatory protein can serve as a reliable marker for parasite clearance in Chagas' disease, aiding in cases with ambiguous standard serology.
Answers are grounded in this paper and cite their sources.
May aid clearance assessment in Chagas cases with ambiguous serology; leaves open prospective validation before adoption.
Immunoprecipitation of the purified 160-kDa complement regulatory protein of Trypanosoma cruzi by Chagas' disease patient sera was examined as a possible correlate of the complement-mediated lysis test and as an indicator of parasite clearance. The results presented demonstrate that assessment of the humoral response to this antigen is a useful indicator of parasite clearance and may be particularly helpful in the assessment of some patients for whom other serological tests produce ambiguous results.
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Norris et al. (1994) conducted an observational in Chagas' disease. Assessment of humoral immune response to the Trypanosoma cruzi 160-kDa complement regulatory protein was evaluated on Parasitologic clearance. Assessment of the humoral response to the Trypanosoma cruzi 160-kDa complement regulatory protein is a useful indicator of parasite clearance in patients with Chagas' disease.
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