Key result
The rTc24 ELISA and Western blot tests identified active infection in all uncured patients and agreed with negative complement-mediated lysis tests in ~80% of parasitologically cured patients.
Why the study?
Does rTc24 evaluated by ELISA and Western blot accurately identify parasitological cure in treated chagasic patients compared to the complement-mediated lysis test?
Observational
Does rTc24 evaluated by ELISA and Western blot accurately identify parasitological cure in treated chagasic patients compared to the complement-mediated lysis test?
The rTc24 recombinant antigen can identify most, but not all, cases of parasitological cure in treated chagasic patients, offering a simpler alternative to the complement-mediated lysis test.
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rTc24 ELISA/WB may simplify Chagas cure assessment; leaves open prospective validation before clinical adoption.
Krautz et al. (1995) conducted an observational in Chagas' disease. 24-kDa Trypanosoma cruzi recombinant protein (rTc24) ELISA and Western blot vs. Complement-mediated lysis test was evaluated on Reactivity to rTc24. The rTc24 ELISA and Western blot tests identified active infection in all uncured patients and agreed with negative complement-mediated lysis tests in ~80% of parasitologically cured patients.
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