Hippadine, an alkaloid of the Amaryllidaceae, produced reversible inhibition of fertility in male rats. A decrease in the testicular weight and DNA content and an increase in protein concentration indicated a fall in the relative proportion of freshly divided cells. The weights of accessory sex organs revealed continued production of androgens. A plausible mechanism for this biochemical function of hippadine is envisaged. Key Word Index Hippadine - Crinum species - Amaryllidaceae - 4,5-Etheno-8,9-methylenedioxy-6-phenanthridone - Alkaloids - Testicular function - Spermatocytogenesis - Antifertility agent
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Chattopadhyay et al. (1983) studied this question.