Key result
Stentless biological prostheses resulted in significantly lower peak valve gradients compared to stented prostheses in elderly patients undergoing aortic valve replacement.
Why the study?
Does a stentless biological prosthesis improve peak valve gradient compared to a stented biological prosthesis in elderly patients undergoing aortic valve replacement?
RCT
parallel
Does a stentless biological prosthesis improve peak valve gradient compared to a stented biological prosthesis in elderly patients undergoing aortic valve replacement?
In an intermediate analysis, stentless biological prostheses demonstrated superior early hemodynamic profiles, including lower peak gradients and improved left ventricular mass index at 30 days, compared to stented prostheses in elderly patients.
Supports stentless over stented prostheses for elderly AVR; confirms hemodynamic superiority in this RCT.
OBJECTIVE. The authors assessed an impact of the design of biological prosthesis on efficacy of aortic valve replacement in elderly patients. MATERIAL AND METHODS. Randomized parallel controlled prospective study was carried out. The patients were divided into groups with stented and stentless prostheses. A value of peak valve gradient was determined as a primary end point. RESULTS. The peak gradients were significantly higher in the first group than in the second group. There was noted a significant difference in value of miocardial hypertrophy of the left ventricular (mass index of the myocardium) during 30-day terms after operation. CONCLUSIONS. The final results would be possible to consider after the end of the study. The results of intermediate analysis supported the validity of the proposed hypothesis.
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Астапов et al. (2017) conducted an RCT in Aortic valve replacement. Stentless biological prostheses vs. Stented biological prostheses was evaluated on Peak valve gradient. Stentless biological prostheses resulted in significantly lower peak valve gradients compared to stented prostheses in elderly patients undergoing aortic valve replacement.
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