Key result
A newborn with a single copy variant of the MTHFR C677T mutation suffered a massive myocardial infarction during birth due to an occluding thrombus in the proximal left coronary artery.
Case Report (n=1)
Heterozygous MTHFR C677T mutation may be a predisposing factor for neonatal coronary thrombosis and myocardial infarction.
Heterozygous MTHFR C677T may predispose to neonatal coronary thrombosis; hypothesis-generating and should not change practice without confirmation.
Neonatal myocardial infarction secondary to congenital heart disease, anomalous coronary artery anatomy, thromboembolism, coagulopathy, birth asphyxia, and unknown causes has been previously reported. We now report an infant who suffered a massive myocardial infarction during birth, requiring extensive resuscitation and aggressive management. A thrombus, the origin of which was not detected on autopsy, was found occluding the proximal left coronary artery several hours after birth. Genetic studies revealed a single copy variant of the MTHFR C677T mutation that we speculate may have predisposed the infant to coronary thrombosis.
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Clark et al. (2012) conducted a case report in Neonatal myocardial infarction (n=1). Heterozygous MTHFR C677T mutation was evaluated on Myocardial infarction and coronary thrombosis. A newborn with a single copy variant of the MTHFR C677T mutation suffered a massive myocardial infarction during birth due to an occluding thrombus in the proximal left coronary artery.
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