Key result
Disseminated intravascular and vegetative cardiac thrombosis was characterized in 24 neonates as a distinct syndrome of platelet thrombosis, suggesting heparin therapy may be detrimental.
Observational (n=24)
Identifies a distinct syndrome of disseminated intravascular and vegetative cardiac thrombosis in neonates, characterized by platelet thrombosis rather than fibrin deposition, suggesting heparin therapy may be detrimental.
May warrant heparin caution in affected neonates; hypothesis-generating case series requiring prospective validation.
The syndrome of disseminated intravascular and vegetative cardiac thrombosis occurred in 24 neonates. The syndrome, characterized by platelet thrombosis and cardiac valve platelet masses, is distinctly different from disseminated intravascular coagulation and resultant fibrin deposition in blood vessels without cardiac valve involvement. Speculations on cause and pathogenesis are made, and possible detrimental effects of heparin therapy are pointed out, since the disorder is one of platelet thrombosis rather than coagulation and fibrin development.
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Blaise E. Favara (1974) conducted an observational in Disseminated intravascular and vegetative cardiac thrombosis (n=24). Disseminated intravascular and vegetative cardiac thrombosis was characterized in 24 neonates as a distinct syndrome of platelet thrombosis, suggesting heparin therapy may be detrimental.
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