Key result
PAI-1 4G/4G homozygosity was associated with the development of rare perinatal myocardial infarction and arterial thrombosis in a case of monozygotic newborn twins.
Highlights a rare case of perinatal myocardial infarction and arterial thrombosis associated with PAI-1 4G/4G homozygosity in identical twins.
Hypothesis-generating for PAI-1 4G/4G in perinatal thrombosis; does not support practice change without further evidence.
Myocardial infarction in the perinatal period, in the absence of congenital heart disease or coronary artery lesions, is rare. The most common etiology described are the thromboembolism and perinatal asphyxia. We report a case of monozygotic twins who developed, after birth, acute vascular events and both had PAI-1 4G/4G homozygosity.
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Lucia et al. (2008) studied this question. PAI-1 4G/4G homozygosity was associated with the development of rare perinatal myocardial infarction and arterial thrombosis in a case of monozygotic newborn twins.
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