Key result
The PAI-1 4G/5G genotype was associated with increased odds of coronary artery occlusion in myocardial infarction compared to homozygous genotypes (OR 1.656; 95% CI 1.009-2.718; p=0.046).
Why the study?
Does the PAI-1 4G/5G genotype increase the risk of coronary artery occlusion in patients with myocardial infarction?
Observational (n=376)
Does the PAI-1 4G/5G genotype increase the risk of coronary artery occlusion in patients with myocardial infarction?
Odds Ratio: 1.656 (95% CI 1.009–2.718)
p-value: p=0.046
Carriers of the PAI-1 4G/5G genotype with myocardial infarction have a 1.6-fold increased odds of coronary artery occlusion compared to homozygous carriers.
PAI-1 4G/5G association with MI occlusion is hypothesis-generating; prospective studies needed before any clinical consideration.
OBJECTIVE: Data on the impact of PAI-1-675 4G/5G genotype for fibrinolysis during myocardial infarction are inconsistent. The aim of our study was to evaluate the association of clinical and genetic (PAI-1-675 4G/5G polymorphism) factors with coronary artery occlusion in patients with myocardial infarction. MATERIALS AND METHODS: PAI-1-675 4G/5G detection was achieved by using Sanger sequencing in a sample of patients hospitalized for stent implantation due to myocardial infarction. We categorized the patients into two groups: patients with coronary artery occlusion and patients without coronary artery occlusion according to angiographic evaluation. RESULTS: We identified n = 122 (32.4%) 4G/4G, n = 186 (49.5%) 4G/5G, and n = 68 (18.1%) 5G/5G PAI-1 genotype carriers. Univariate and multivariate analysis showed that only the 4G/5G genotype was associated with coronary artery occlusion (OR: 1.656 and 95% CI: 1.009-2.718, p = 0.046). CONCLUSIONS: Our results showed that carriers of PAI-1 4G/5G genotype with myocardial infarction have increased odds of coronary artery occlusion more than 1.6 times in comparison to the carriers of homozygous genotypes.
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Parpugga et al. (2015) conducted an observational in Myocardial infarction (n=376). PAI-1 4G/5G genotype vs. Homozygous genotypes (4G/4G and 5G/5G) was evaluated on Coronary artery occlusion (OR 1.656, 95% CI 1.009-2.718, p=0.046). The PAI-1 4G/5G genotype was associated with increased odds of coronary artery occlusion in myocardial infarction compared to homozygous genotypes (OR 1.656; 95% CI 1.009-2.718; p=0.046).
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