What question did this study set out to answer?

To assess the efficacy of supralethal chemotherapy, radiation therapy, and bone marrow reconstitution in pediatric patients with recurrent metastatic neuroblastoma.

June 1, 1984Journal of Clinical Oncology

Treatment of advanced neuroblastoma with supralethal chemotherapy, radiation, and allogeneic or autologous marrow reconstitution.

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Authors

CACharles S. AugustSprint (United States)FSFredric T. SerotaChildren's Hospital of Philadelphia PKP. KochHôpital Kirchberg

Discussion

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Implication

Clinical study reports durable remission in recurrent neuroblastoma after supralethal chemoradiotherapy and marrow rescue, indicating potential disease control.

Key Points

To assess the efficacy of supralethal chemotherapy, radiation therapy, and bone marrow reconstitution in pediatric patients with recurrent metastatic neuroblastoma.
Treated 10 children with recurrent metastatic (stage IV) neuroblastoma with local radiation therapy, supralethal chemotherapy, total-body irradiation, and bone marrow rescue.
Administered allogeneic (n=4) or autologous (n=6) marrow rescue following either individualized chemotherapy regimens (first two patients) or a standardized regimen of VM-26, doxorubicin, melphalan, and 1,000-rad fractionated total-body irradiation (remaining eight patients).
Four of 10 children achieved long-term complete remission: two allogeneic recipients survived for 54 and 36 months, and two autologous recipients survived for 35 and 22 months.
Six patients died: two after individualized therapy at 3 and 9 months, three from disseminated fungal infections in the early posttransplant period, and one from tumor relapse at 9 months.

Cite This Study

August et al. (1984) studied this question.

synapsesocial.com/papers/6a9ed90a04d883a0111cd84f https://doi.org/10.1200/jco.1984.2.6.609

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Implication

Clinical study reports durable remission in recurrent neuroblastoma after supralethal chemoradiotherapy and marrow rescue, indicating potential disease control.

Treatment of advanced neuroblastoma with supralethal chemotherapy, radiation, and allogeneic or autologous marrow reconstitution.

Discussion

Member takes

Implication

Key Points

Cite This Study

Treatment of advanced neuroblastoma with supralethal chemotherapy, radiation, and allogeneic or autologous marrow reconstitution.

Discussion

Member takes

Implication

Key Points

Cite This Study

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