Risk-Reducing Salpingo-Oophorectomy in Patients at High Risk of Epithelial Ovarian and Fallopian Tube Cancer: A Review Article

Background: Risk-reducing bilateral salpingo-oophorectomy (RRBSO) is a surgical procedure in which the fallopian tubes and ovaries are surgically removed from patients who have a heightened susceptibility to epithelial ovarian carcinoma including those with BRCA1 and BRCA2 mutations. It represents the most efficacious approach to mitigating the risk of these malignancies in high-risk patients and to improve women's overall survival rate. Aim: The purpose of this article is to explore Risk-reducing bilateral salpingo-oophorectomy (RRBSO) in patient who are at high risk of epithelial ovarian cancer and fallopian tube cancer. Materials and Methods: A web-based literature search was conducted utilizing the advanced features of several databases, including PubMed, Scopus, Embase, Google Scholar, the Directory of Open Access Journals (DOAJ), and Cochrane. The keywords that were used included: Risk-Reducing Salpingo-Oophorectomy (RRBSO), Epithelial Ovarian, Fallopian Tube Cancer.Conclusion: Risk-reducing bilateral salpingo-oophorectomy (RRBSO) has been shown to improve the survival rate of women that are at high risk of epithelial ovarian cancer especially in those with BRCA 1 and 2 mutations. It has also been associated with a decreased breast cancer risk in BRCA carriers without a history of the disease. There is a 2% chance that cases at high risk for ovarian cancer will develop primary peritoneal carcinoma; this risk remains even after Risk-reducing bilateral salpingo-oophorectomy. It is recommended that a risk-reducing bilateral salpingo-oophorectomy be performed between the ages of 35 and 40, or as soon as a patient's family is complete. Hormonal replacement therapy is an effective treatment for symptoms following Risk-reducing bilateral salpingo-oophorectomy.